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Factors influencing lipogenesis and lipolysis FACTORS INFLUENCING LIPOGENESIS AND LIPOLYSIS
Although fat moves continuously through the fat cycle, at times lipogenesis dominates and at other times lipolysis dominates. The overwhelming factor influencing the balance is the state of feeding, with fasting favouring lipolysis and feeding favouring lipogenesis, as already discussed. These directly correspond to the demand for fat as fuel.
Another condition which favours lipolysis is stress, either physical or psychological, such as exercise or a fearful situation. Adrenalin causes an increase in lipolysis with FFAs being released into the bloodstream anticipating a demand for fat as fuel. If the situation passes without the need to use the extra energy, such as with exercise, the fat returns from the fat cycle back to the fat cell In other words, an increase in lipolysis does not always correspond to an increase in fat utilisation for energy.
A number of other factors can influence the balance of lipolysis and lipogenesis. A large fat mass tends to increase the amount of lipolysis and thus the amount of FFAs available for energy needs. Insulin, catecholamines, Cortisol and sex hormone levels can also alter the balance. Fat cells in the hips, buttocks and breast are more responsive to female hormones than the fat cells on the abdomen, which are more prolific in men.
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